Hi Marc,
It depends what you mean by 'best performance'.
Don't forget these motors are fairly high revving - top-end ones are revving to and beyond 20k revs. They rely on there being enough oil in the fuel/oil mixture to permit adequate lubrication, or you'll promote premature wear.
Weed whacker motors don't rev anywhere near we're told. I'm guessing up to 12-13k. On this alone, you'll see people using 50:1 fuel

il ratios.
DO NOT use this on a largescale motor, for the previously-mentioned reasons.
Theoretically, YES, you'll get more power, but LESS lubrication, and it'll run hotter, probably.
Most racers, and hour-on-hour bashers rely on a 25:1 ratio, but using a very good quality oil.
I use mine for up to an hour or so, and have used top-grade Castrol synthetic 2-stroke oil from the start, and mix at 32:1. I've not had any problems so far.
Hope this helps.
Al.